Inhibition of Parental and Mutant Xanthosine S-Phosphate Aminases by Psicofuranine*

Abstract

The antibiotic psicofuranine (9-n-psicofuranosy-6-aminopurine) causes a guanine deficiency in enteric bacteria (1) through inhibition of xanthosine 5’-phosphate (XMP) aminase (2), an enzyme essential for guanine nucleotide synthesis (3). A study of the mechanism of the inhibition was undertaken as a preliminary to the biochemical analysis of psicofuranine… (More)

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Cite this paper

@inproceedings{Udaka2003InhibitionOP, title={Inhibition of Parental and Mutant Xanthosine S-Phosphate Aminases by Psicofuranine*}, author={Shigezo Udaka}, year={2003} }