Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist

@article{Noguchi2001InhibitionOP,
  title={Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist},
  author={Kazumi Noguchi and Hiroji Uemura and Masao Harada and Takeshi Miura and Masatoshi Moriyama and Hiroshi Fukuoka and Kazuo Kitami and Masahiko Hosaka},
  journal={International Journal of Clinical Oncology},
  year={2001},
  volume={6},
  pages={29-33}
}
AbstractBackground. A prospective randomized study was designed to determine whether flutamide (FLU) administered before treatment with a luteinizing hormone-releasing hormone agonist (LH-RHa) prevented prostate-specific antigen (PSA) flare in prostate cancer patients. Methods. Prostate cancer patients were randomized into two groups and received either FLU (n = 11) or no pretreatment (n = 13) for 2 weeks before the initial injection of LH-RHa. LH-RHa (every 4 weeks) and FLU (every day) were… 
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