Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist

@article{Noguchi2001InhibitionOP,
  title={Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist},
  author={Kazumi Noguchi and Hiroji Uemura and Masao Harada and Takeshi Miura and Masatoshi Moriyama and Hiroshi Fukuoka and Kazuo Kitami and Masahiko Hosaka},
  journal={International Journal of Clinical Oncology},
  year={2001},
  volume={6},
  pages={29-33}
}
AbstractBackground. A prospective randomized study was designed to determine whether flutamide (FLU) administered before treatment with a luteinizing hormone-releasing hormone agonist (LH-RHa) prevented prostate-specific antigen (PSA) flare in prostate cancer patients. Methods. Prostate cancer patients were randomized into two groups and received either FLU (n = 11) or no pretreatment (n = 13) for 2 weeks before the initial injection of LH-RHa. LH-RHa (every 4 weeks) and FLU (every day) were… 
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Background Citations
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Results Citations
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21 Citations

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Degarelix monotherapy compared with luteinizing hormone-releasing hormone (LHRH) agonists plus anti-androgen flare protection in advanced prostate cancer: an analysis of two randomized controlled trials
TLDR
Degarelix monotherapy produced a more favorable effect on PSA PFS outcomes than a LHRH agonist + AA flare protection therapy in patients with prostate cancer when a case-control analysis was used to compensate for differences between treatment groups.
Impact of PSA flare-up in patients with hormone-refractory prostate cancer undergoing chemotherapy
TLDR
Evidence is shown that co-medication with dexamethasone/prednisolone and/or estramustine itself can induce an initial PSA flare-up via androgen receptor mutations, and Chemotherapy should be continued a minimum of six weeks before removing patients from a docetaxel-based regimen.
Early abiraterone acetate treatment is beneficial in Japanese castration-resistant prostate cancer after failure of primary combined androgen blockade
Clinical significance of a prostate-specific antigen flare phenomenon in patients with hormone-refractory prostate cancer receiving docetaxel
TLDR
An initial rise of prostate-specific antigen under docetaxel therapy in hormone-refractory prostate cancer does not indicate therapeutic failure and should not lead to early withdrawal from therapy in the absence of clinical signs of progression.
Risk of disease flare with LHRH agonist therapy in men with prostate cancer: myth or fact?
Prostate-specific antigen flare induced by 223RaCl2 in patients with metastatic castration-resistant prostate cancer
TLDR
This report suggests that a flare does not necessarily indicate lack of response to 223RaCl2 therapy, and the tumor burden reduction, expressed by ΔTLF10 and ΔFTV10, was more evident within PSA flare group below baseline than non-responders.
Prognostic role of early PSA drop in castration resistant prostate cancer patients treated with abiraterone acetate or enzalutamide.
TLDR
This retrospective study evaluates the prognostic role of early PSA drop in metastatic castration resistant prostate cancer patients receiving abiraterone acetate (AA) or enzalutamide (E) and found that mCRPC patients treated with AA or E, in docetaxel-naïve or post-docetaxe setting, had significantly better OS and PFS.
Patterns of Bicalutamide Use in Prostate Cancer Treatment: A U.S. Real-World Analysis Using the SEER-Medicare Database
TLDR
Although there is no FDA indication for BIC use as monotherapy, 44% of patients in this study used BIC alone or as part of CAB followed by monotherapy; further research is necessary to understand the outcomes of BIC utilization in these settings, particularly compared with newer second-generation anti-androgens.
Prostate‐Specific Antigen Flare Phenomenon Induced by Abiraterone Acetate in Chemotherapy‐Naive Patients With Metastatic Castration‐Resistant Prostate Cancer
Risk of Testosterone Flare in the Era of the Saturation Model: One More Historical Myth.
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