Inhibition of PPARgamma prevents type I diabetic bone marrow adiposity but not bone loss.

@article{Botolin2006InhibitionOP,
  title={Inhibition of PPARgamma prevents type I diabetic bone marrow adiposity but not bone loss.},
  author={Sergiu Botolin and Laura R McCabe},
  journal={Journal of cellular physiology},
  year={2006},
  volume={209 3},
  pages={967-76}
}
Diabetes type I is associated with bone loss and increased bone adiposity. Osteoblasts and adipocytes are both derived from mesenchymal stem cells located in the bone marrow, therefore we hypothesized that if we could block adipocyte differentiation we might prevent bone loss in diabetic mice. Control and insulin-deficient diabetic BALB/c mice were chronically treated with a peroxisomal proliferator-activated receptor gamma (PPARgamma) antagonist, bisphenol-A-diglycidyl ether (BADGE), to block… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…