Inhibition of PMCA activity by tau as a function of aging and Alzheimer's neuropathology.

@article{Berrocal2015InhibitionOP,
  title={Inhibition of PMCA activity by tau as a function of aging and Alzheimer's neuropathology.},
  author={Mar{\'i}a Berrocal and Isaac Corbacho and Mar{\'i}a Olivia V{\'a}zquez-Hern{\'a}ndez and Jes{\'u}s {\'A}vila and Maria Rosario Sep{\'u}lveda and Ana Teresa Mata},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 7},
  pages={1465-76}
}
Ca2+-ATPases are plasma membrane and intracellular membrane transporters that use the energy of ATP hydrolysis to pump cytosolic Ca2+ out of the cell (PMCA) or into internal stores. These pumps are the main high-affinity Ca2+ systems involved in the maintenance of intracellular free Ca2+ at the properly low level in eukaryotic cells. The failure of neurons to keep optimal intracellular Ca2+ concentrations is a common feature of neurodegeneration by aging and aging-linked neuropathologies, such… CONTINUE READING
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