Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.

  title={Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.},
  author={Yan-qin Li and Yan-xue Xue and Ying-ying He and Fang-qiong Li and Li-fen Xue and Chun-mei Xu and Todd Charlton Sacktor and Yavin Shaham and Lin Lu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 14},
During abstinence, memories of drug-associated cues persist for many months, and exposure to these cues often provokes relapse to drug use. The mechanisms underlying the maintenance of these memories are unknown. A constitutively active atypical protein kinase C (PKC) isozyme, protein kinase M ζ (PKMζ), is required for maintenance of spatial memory, conditioned taste aversion, and other memory forms. We used conditioned place preference (CPP) and conditioned place aversion (CPA) procedures to… CONTINUE READING
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