Inhibition of PKCalpha and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide.

@article{Taggart2000InhibitionOP,
  title={Inhibition of PKCalpha and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide.},
  author={Michael J. Taggart and Paul Leavis and Olivier F{\'e}ron and Kathleen G Morgan},
  journal={Experimental cell research},
  year={2000},
  volume={258 1},
  pages={72-81}
}
Receptor-coupled contraction of smooth muscle involves recruitment to the plasma membrane of downstream effector molecules PKCalpha and rhoA but the mechanism of this signal integration is unclear. Caveolins, the principal structural proteins of caveolar plasma membrane invaginations, have been implicated in the organization and regulation of many signal transducing molecules. Thus, using laser scanning confocal immunofluorescent microscopy, we tested the hypothesis that caveolin is involved in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle.

American journal of physiology. Gastrointestinal and liver physiology • 2007
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…