Inhibition of PKC disrupts addiction-related memory

  title={Inhibition of PKC disrupts addiction-related memory},
  author={Kristin K. Howell and Bradley R. Monk and Stephanie A. Carmack and Oliver D Mrowczynski and Robert D. Clark and Stephan G. Anagnostaras},
  booktitle={Front. Behav. Neurosci.},
The atypical PKC isoforms, PKMζ and PKCλ have been proposed as integral substrates of long-term memory (LTM). Inhibition of these isoforms has recently been demonstrated to be sufficient for impairing the expression and maintenance of long-term potentiation. Additionally, the pseudosubstrate inhibitor, zeta inhibitory peptide (ZIP), which effectively blocks… CONTINUE READING