Inhibition of PKC‐Induced COX‐2 and IL‐8 Expression in Human Breast Cancer Cells by Glucosamine

@article{Chou2015InhibitionOP,
  title={Inhibition of PKC‐Induced COX‐2 and IL‐8 Expression in Human Breast Cancer Cells by Glucosamine},
  author={W Y Chou and Kun-Han Chuang and David Sun and Yu-Hsiu Lee and Pu-Hong Kao and Yen-Yu Lin and Hsei-Wei Wang and Yuh-Lin Wu},
  journal={Journal of Cellular Physiology},
  year={2015},
  volume={230}
}
Breast cancer is a common cancer leading to many deaths among females. Cyclooxygenase‐2 (COX‐2) and interleukin‐8 (IL‐8) are two highly expressed inflammatory mediators to be induced by the protein kinase C (PKC) signaling via various inflammatory stimuli and both contribute significantly to cancer metastasis/progression. Glucosamine has been shown to act as an anti‐inflammation molecule. The aim of this study was to clarify the role and acting mechanism of glucosamine during the PKC‐regulation… Expand
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