Inhibition of PI3K Signalling Selectively Affects Medulloblastoma Cancer Stem Cells

@inproceedings{Frasson2015InhibitionOP,
  title={Inhibition of PI3K Signalling Selectively Affects Medulloblastoma Cancer Stem Cells},
  author={Chiara Frasson and Elena Rampazzo and Benedetta Accordi and Giacomo Beggio and Francesca Pistollato and Giuseppe Basso and Luca Persano},
  booktitle={BioMed research international},
  year={2015}
}
Medulloblastoma is the most common malignant brain tumor of childhood. Although survival has slowly increased in the past years, the prognosis of these patients remains unfavourable. In this context, it has been recently shown that the intracellular signaling pathways activated during embryonic cerebellar development are deregulated in MDB. One of the most important is PI3K/AKT/mTOR, implicated in cell proliferation, survival, growth, and protein synthesis. Moreover, a fraction of MDB cells has… CONTINUE READING