Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

@article{Flynn2000InhibitionOP,
  title={Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival},
  author={Peter Flynn and Michelle Wong† and Maryam Zavar and Nicholas M. Dean and David Stokoe},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={1439-1442}
}
3-Phosphoinositide-dependent kinase-1 (PDK-1) was identified by its ability to phosphorylate and activate protein kinase B (PKB) in vitro [1,2] and can phosphorylate and activate additional protein kinases in the AGC family in vitro [3-6]. Its role in vivo has, however, only begun to be addressed. We used antisense oligonucleotides directed against PDK-1 expression to explore the role of PDK-1 in human glioblastoma cells (U87-MG), which express a mutant PTEN allele. Reduction in PDK-1 levels… CONTINUE READING