Inhibition of PC-12 cell differentiation by the immediate early gene fra-1.

@article{Ito1990InhibitionOP,
  title={Inhibition of PC-12 cell differentiation by the immediate early gene fra-1.},
  author={Etsuro Ito and L A Sweterlitsch and Phuong B. Tran and F. Rauscher and Ramaswamy Narayanan},
  journal={Oncogene},
  year={1990},
  volume={5 12},
  pages={1755-60}
}
The rat pheochromocytoma cell line (PC-12) offers a powerful in vitro model to study the mechanism of growth factor-induced differentiation and proliferation. Within minutes of addition, agents such as nerve growth factor (NGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and dibutyryl cyclic AMP (db cAMP) rapidly activate cellular immediate early genes such as c-fos, c-jun, jun-B, and egr-1. fra-1, a member of the immediate early gene family, follows a distinctly later… CONTINUE READING