Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.

@article{Peters2002InhibitionOP,
  title={Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.},
  author={Gregory A. Peters and David ES Khoo and Ian J. Mohr and Ganes C Sen},
  journal={Journal of virology},
  year={2002},
  volume={76 21},
  pages={11054-64}
}
PACT, a protein activator of PKR, can cause inhibition of cellular protein synthesis and apoptosis. Here, we report that the Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo. Although Us11 can bind to both PKR and PACT, mutational analyses revealed that the binding of Us11 to PKR, and not to PACT, was essential for its inhibitory action. Similar analyses also revealed that the inhibitory effect was mediated by an interaction between the C… CONTINUE READING

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