Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

@article{Chu2011InhibitionOP,
  title={Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus},
  author={Ke-tan Chu and Bo Yin and Jingye Wang and Guoping Peng and Hui Liang and Ziqi Xu and Yue Du and Marong Fang and Qiang Xia and Benyan Luo},
  journal={Journal of Neuroinflammation},
  year={2011},
  volume={9},
  pages={69 - 69}
}
BackgroundNeuroinflammation plays an important role in cerebral ischemia/reperfusion (I/R) injury. The P2X7 receptor (P2X7R) has been reported to be involved in the inflammatory response of many central nervous system diseases. However, the role of P2X7Rs in transient global cerebral I/R injury remains unclear. The purpose of this study is to determine the effects of inhibiting the P2X7R in a rat model of transient global cerebral I/R injury, and then to explore the association between the… Expand
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