Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative† †Electronic supplementary information (ESI) available: All experimental, spectroscopic details and supplemental figures. See DOI: 10.1039/c6sc02103d

@inproceedings{Zheng2016InhibitionOP,
  title={Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative†
†Electronic supplementary information (ESI) available: All experimental, spectroscopic details and supplemental figures. See DOI: 10.1039/c6sc02103d
},
  author={Yue Kun Zheng and Genichiro Tsuji and Clement Opoku-Temeng and Herman O Sintim},
  booktitle={Chemical science},
  year={2016}
}
Various important cellular processes in bacteria are controlled by c-di-GMP, such as motility, biofilm formation and virulence factors production. C-di-GMP is synthesized from two molecules of GTP by diguanylate cyclases (DGCs) and its actions are terminated by EAL or HD-GYP domain phosphodiesterases (PDEs), which hydrolyze c-di-GMP to linear pGpG or GMP. Thus far the majority of efforts have been dedicated to the development of inhibitors of DGCs but not PDEs. This is probably because the old… CONTINUE READING
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