Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients.

@article{Engdal2008InhibitionOP,
  title={Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients.},
  author={Silje Engdal and Odd Georg Nilsen},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2008},
  volume={38 6},
  pages={559-73}
}
1. The herbal products Natto K2, Agaricus, mistletoe, noni juice, green tea and garlic were investigated for in vitro inhibitory potential on P-glycoprotein (P-gp)-mediated transport of digoxin (30 nM) in differentiated and polarized Caco-2 cells. 2. Satisfactory cell functionality was demonstrated through measurements of assay linearity, transepithelial electric resistance (TEER), cytotoxicity, mannitol permeability, and inclusion of the positive inhibition control verapamil. 3. The most… CONTINUE READING
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