Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells.

@article{Lee2009InhibitionOP,
  title={Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells.},
  author={Eibai Lee and Riyo Enomoto and Chika Koshiba and Hiroyuki Hirano},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1171},
  pages={
          132-6
        }
}
Etoposide induces apoptotic cell death in normal and cancer cells. This apoptosis plays a role not only in anticancer effects but also in adverse reactions, such as myelosuppression. Because we had previously found that wogonin, a flavone found in a plant, suppresses thymocyte apoptosis induced by etoposide, we examined the effect of this flavone in cancer cells. Wogonin significantly potentiated etoposide-induced apoptosis in HL-60 cells. This flavone impaired the function of P-glycoprotein… CONTINUE READING
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