• DOI:10.3181/00379727-157-40080
Corpus ID: 1111454

Inhibition of Oxytocin Release by Morphine and Its Analogs

@article{Haldar1978InhibitionOO,
  title={Inhibition of Oxytocin Release by Morphine and Its Analogs},
  author={J. Haldar and W. H. Sawyer},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1978},
  volume={157},
  pages={476 - 480}
}

J. Haldar, W. H. Sawyer

Published 1978

Chemistry, Medicine

Proceedings of the Society for Experimental Biology and Medicine

Summary Two synthetic morphine analogs, butorphanol and oxilorphan have been found to inhibit suckling induced oxytocin (OT) release in lactating mice. Morphine when tested in a similar experimental set-up produced even greater inhibition. Naloxone could effectively block inhibitions induced both by butorphanol and by morphine. When injected alone, naloxone did not produce any inhibition. These results indicate that (a) butorphanol, oxilorphan and morphine inhibit suckling induced OT release in… CONTINUE READING

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