Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7/Osteogenic Protein 1

@inproceedings{Maurer2012InhibitionOO,
  title={Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7/Osteogenic Protein 1},
  author={Thomas Maurer and Gerald Zimmermann and Susanne Maurer and Sabine Stegmaier and Christof Wagner and Gertrud Maria Haensch},
  booktitle={Mediators of inflammation},
  year={2012}
}
Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFκB (RANK) ligand, tumor necrosis factor (TNF) α, or interleukin- (IL-) 8 have be identified as inducers of osteoclastogenesis, whereas others, such as IL-10 or transforming growth factor (TGF)ß inhibit osteoclast generation or induce differentiation towards a dendritic cell type. We now… CONTINUE READING