Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α.

  title={Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α.},
  author={Linda C. Gilbert and Xiaofei He and Paul Farmer and Scott D. Boden and Mirek Kozlowski and Janet Rubin and Mark S. Nanes},
  volume={141 11},
Tumor necrosis factor-a (TNF-a) has a key role in skeletal disease in which it promotes reduced bone formation by mature osteoblasts and increased osteoclastic resorption. Here we show that TNF inhibits differentiation of osteoblasts from precursor cells. TNF-a treatment of fetal calvaria precursor cells, which spontaneously differentiate to the osteoblast phenotype over 21 days, inhibited differentiation as shown by reduced formation of multilayered, mineralizing nodules and decreased… CONTINUE READING


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