Inhibition of la-O-TetradecanoylphorboMS-acetate-induced Ornithine Decarboxylase Activity in Mouse Epidermis by Vitamin A Analogs (Retinoids)1

Abstract

Application of the potent tumor-promoting agent 12-Otetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a rapid and transient induction of epidermal ornithine decarboxylase (EC 4.1.1.17) activity. Several lines of evidence, including the finding that /3-retinoic acid inhibits both phorbol ester-induced ornithine decarboxyl ase activity and the… (More)

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