Inhibition of OCTN2-Mediated Transport of Carnitine by Etoposide

@article{Hu2012InhibitionOO,
  title={Inhibition of OCTN2-Mediated Transport of Carnitine by Etoposide},
  author={Chaoxin Hu and Cynthia S. Lancaster and Zhili Zuo and Shuiying Hu and Zhaoyuan Chen and Jeffrey E. Rubnitz and Sharyn D. Baker and Alex Sparreboom},
  journal={Molecular Cancer Therapeutics},
  year={2012},
  volume={11},
  pages={921 - 929}
}
OCTN2 is a bifunctional transporter that reabsorbs filtered carnitine in a sodium-dependent manner and secretes organic cations into urine as a proton antiport mechanism. We hypothesized that inhibition of OCTN2 by anticancer drugs can influence carnitine resorption. OCTN2-mediated transport inhibition by anticancer drugs was assessed using cells transfected with human OCTN2 (hOCTN2) or mouse Octn2 (mOctn2). Excretion of carnitine and acetylcarnitine was measured in urine collected from mice… 

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