Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.

Abstract

Drug resistance remains a critical problem in the treatment of patients with multiple myeloma. Recent studies have determined that Notch signaling plays a major role in bone marrow (BM) stroma-mediated protection of myeloma cells from de novo drug-induced apoptosis. Here, we investigated whether pharmacologic inhibition of Notch signaling could affect the… (More)

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@article{Nefedova2008InhibitionON, title={Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.}, author={Yulia Nefedova and Daniel Sullivan and Sophia C. E. Bolick and William S Dalton and Dmitry I Gabrilovich}, journal={Blood}, year={2008}, volume={111 4}, pages={2220-9} }