Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer

@article{Ikezawa2016InhibitionON,
  title={Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer},
  author={Yasuyuki Ikezawa and Jun Sakakibara-Konishi and Hidenori Mizugaki and Satoshi Oizumi and Masaharu Nishimura},
  journal={International Journal of Clinical Oncology},
  year={2016},
  volume={22},
  pages={59-69}
}
The Notch receptor plays an important role in various cell fate decisions during development and in cancer. We have previously reported that Notch3 is upregulated by radiation in non-small cell lung cancer (NSCLC) cell lines and that the Notch pathway inhibitor γ secretase inhibitor GSI (gamma-secretase inhibitor), when combined with radiation therapy, significantly suppressed the growth of lung cancer cells. However, little is known about the mechanism of Notch upregulation induced by… CONTINUE READING