Inhibition of Nitric Oxide Synthase by L-NAME Promotes Cisplatin-Induced Nephrotoxicity in Male Rats

@inproceedings{Moslemi2013InhibitionON,
  title={Inhibition of Nitric Oxide Synthase by L-NAME Promotes Cisplatin-Induced Nephrotoxicity in Male Rats},
  author={Fatemeh Moslemi and Mehdi Nematbakhsh and Fatemeh Eshraghi-Jazi and Ardeshir Talebi and Hamid Nasri and Farzaneh Ashrafi and Maryam Moeini and Azam Mansouri and Zahra Pezeshki},
  booktitle={ISRN toxicology},
  year={2013}
}
Objective. Nitric oxide (NO) has numerous important functions in the kidney. The role of NO in cisplatin (CP)-induced nephrotoxicity is not completely understood. This study was designed to determine the role of NO synthase inhibitor (L-NAME) on the severity of CP-induced nephrotoxicity in rats. Methods. Sixty four male (M) and female (F) Wistar rats were… CONTINUE READING