Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions

@inproceedings{Wang2015InhibitionON,
  title={Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions},
  author={Zejun Wang and Boris Tabakoff and Simon Rock Levinson and Thomas Heinbockel},
  booktitle={Acta Pharmacologica Sinica},
  year={2015}
}
Aim:Methyl eugenol is a major active component extracted from the Chinese herb Asari Radix et Rhizoma, which has been used to treat toothache and other pain. Previous in vivo studies have shown that methyl eugenol has anesthetic and antinociceptive effects. The aim of this study was to determine the possible mechanism underlying its effect on nervous system disorders.Methods:The direct interaction of methyl eugenol with Na+ channels was explored and characterized using electrophysiological… CONTINUE READING
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Role of the local anesthetic receptor in the state-dependent inhibition of voltage-gated sodium channels by the insecticide metaflumizone

  • RT vonStein, DM Soderlund
  • Mol Pharmacol
  • 2012

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