Inhibition of Na+,K+-ATPase by cisplatin and its recovery by 2-mercaptoethanol in human squamous cell carcinoma cells.

@article{Sakakibara1999InhibitionON,
  title={Inhibition of Na+,K+-ATPase by cisplatin and its recovery by 2-mercaptoethanol in human squamous cell carcinoma cells.},
  author={Naoki Sakakibara and Keiichiro Suzuki and Hiroyuki Kaneta and Yoshitaka Yoshimura and Yoshiaki Deyama and Akio Matsumoto and Hiroyuki Fukuda},
  journal={Anti-cancer drugs},
  year={1999},
  volume={10 2},
  pages={203-11}
}
Na+,K+-ATPase (EC 3.6.1.37) is assumed to be involved in the transport of cisplatin [cis-diamminedichloroplatinum(II)] into cells and to act as a modulator of 5-fluorouracil (5-FU) in combination therapy of cisplatin and 5-FU. Whereas inhibition of Na+,K+-ATPase activity by cisplatin is expected to have effects on both anti-cancer therapy and nephrotoxicity, the inhibition mechanism remains to be elucidated. We studied the inhibition of Na+,K+-ATPase activity by cisplatin using an enzyme… CONTINUE READING