Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation.

@article{Diehl2004InhibitionON,
  title={Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation.},
  author={Sean A Diehl and Troy J Krahl and Lisa Rinaldi and Ryan J Norton and Charles G. Irvin and Mercedes Rinc{\'o}n},
  journal={Journal of immunology},
  year={2004},
  volume={172 6},
  pages={3597-603}
}
NFAT is a family of transcription factors important in the regulation of cytokine genes and is widely expressed in different lymphoid and nonlymphoid tissues. Consequently, the role of NFAT in CD4+ T cells during an in vivo immune response is not completely clear. In this study, we use transgenic mice expressing a dominant negative NFAT mutant exclusively in T cells to address the role of NFAT in T cells during a Th2 immune response in a model of allergic airway inflammation. We have observed… CONTINUE READING

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