Inhibition of NF-kappaB stabilizes gadd45alpha mRNA.

  title={Inhibition of NF-kappaB stabilizes gadd45alpha mRNA.},
  author={X Long Zheng and Yadong Zhang and Yu-quan Chen and Vincent Castranova and Xianglin Shi and Erwei Song},
  journal={Biochemical and biophysical research communications},
  volume={329 1},
Growth arrest- and DNA damage-inducible protein alpha (gadd45alpha) is an important regulator for cell cycle, genomic stability, and cell apoptosis. In the present report, we demonstrated that NF-kappaB inhibition due to Ikkbeta deficiency enhanced the stability of gadd45alpha mNRA. Using embryo fibroblast cells derived from wild type (wt) or Ikkbeta gene knockout (Ikkbeta(-/-)) mice, reverse transcription-polymerase chain reaction revealed a three- to fourfold increase of gadd45alpha mRNA in… CONTINUE READING

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