Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.

@article{Kanters2003InhibitionON,
  title={Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.},
  author={Edwin Kanters and Manolis Pasparakis and Marion J. J. Gijbels and Monique N. Vergouwe and Iris E J M Partouns-Hendriks and Remond J. A. Fijneman and Bj{\"o}rn E Clausen and Irmgard Foerster and Mark M. Kockx and K. Rajewsky and Georg Kraal and Marten H. Hofker and Menno P J de Winther},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 8},
  pages={1176-85}
}
Atherosclerosis is now generally accepted as a chronic inflammatory condition. The transcription factor NF-kappaB is a key regulator of inflammation, immune responses, cell survival, and cell proliferation. To investigate the role of NF-kappaB activation in macrophages during atherogenesis, we used LDL receptor-deficient mice with a macrophage-restricted deletion of IkappaB kinase 2 (IKK2), which is essential for NF-kappaB activation by proinflammatory signals. These mice showed increased… CONTINUE READING
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