Inhibition of NF-kappa B by sodium salicylate and aspirin.

  title={Inhibition of NF-kappa B by sodium salicylate and aspirin.},
  author={Elizabeth B Kopp and Sankar Ghosh},
  volume={265 5174},
The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF… CONTINUE READING
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