Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity.

@article{Keifer2001InhibitionON,
  title={Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity.},
  author={Jayne A. Keifer and Denis C. Guttridge and Brian P. Ashburner and Albert S Baldwin},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 25},
  pages={
          22382-7
        }
}
The sedative and anti-nausea drug thalidomide, which causes birth defects in humans, has been shown to have both anti-inflammatory and anti-oncogenic properties. The anti-inflammatory effect of thalidomide is associated with suppression of cytokine expression and the anti-oncogenic effect with inhibition of angiogenesis. It is presently unclear whether the teratogenic properties of thalidomide are connected in any way to the beneficial, anti-disease characteristics of this drug. The… CONTINUE READING

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