Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

@inproceedings{Mathas2003InhibitionON,
  title={Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis},
  author={Stephan Mathas and Andreas Lietz and Martin Janz and Michael A. Hinz and Franziska Jundt and Claus Scheidereit and Kurt Bommert and Reinhold Munker},
  year={2003}
}
Arsenic can induce apoptosis and is an efficient drug for the treatment of acute promyelocytic leukemia. Currently, clinical studies are investigating arsenic as a therapeutic agent for a variety of malignancies. In this study, Hodgkin/Reed-Sternberg (HRS) cell lines served as model systems to characterize the role of nuclear factor–κB (NF-κB) in arsenic-induced apoptosis. Arsenic rapidly down-regulated constitutive IκB kinase (IKK) as well as NF-κB activity and induced apoptosis in HRS cell… CONTINUE READING

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Divergent Effects of Arsenic on NF-κB Signaling in Different Cells or Tissues: A Systematic Review and Meta-Analysis.

  • International journal of environmental research and public health
  • 2016
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