Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis

@article{Bushdid1998InhibitionON,
  title={Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis},
  author={Paul B. Bushdid and Dana M. Brantley and Fiona E Yull and Gareth L. Blaeuer and Loren H. Hoffman and Lee Niswander and Lawrence D. Kerr},
  journal={Nature},
  year={1998},
  volume={392},
  pages={615-618}
}
In Drosophila, the Dorsal protein establishes the embryonic dorso–ventral axis during development. Here we show that the vertebrate homologue of Dorsal, nuclear factor-kappa B (NF-κB), is vital for the formation of the proximo–distal organizer of the developing limb bud, the apical ectodermal ridge (AER). Transcription of the NF-κB proto-oncogene c-rel is regulated, in part, during morphogenesis of the limb bud by AER-derived signals such as fibroblast growth factors. Interruption of NF-κB… CONTINUE READING

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