Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.

@article{Watanabe2013InhibitionON,
  title={Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.},
  author={Ryo Watanabe and Ryoko Wakizono Azuma and Jun-ichi Suzuki and Masahito Ogawa and Akiko Itai and Yukimasa Hirata and Issei Komuro and Mitsuaki Isobe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={305 12},
  pages={
          H1761-71
        }
}
NF-κB, which is activated by the inhibitor of NF-κB kinase (IKK), is involved in the progression of inflammatory disease. However, the effect of IKK inhibition on the progression of myocarditis is unknown. We examined the effect of IKK inhibition on the progression of myocarditis. Lewis rats were immunized with porcine cardiac myosin to induce experimental autoimmune myocarditis (EAM). We administered the IKK inhibitor (IMD-0354; 15 mg·kg(-1)·day(-1)) or vehicle to EAM rats daily. Hearts were… CONTINUE READING

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