Inhibition of NF-κ B activity and cFLIP expression contribute to viral-induced apoptosis

@article{Clarke2005InhibitionON,
  title={Inhibition of NF-κ B activity and cFLIP expression contribute to viral-induced apoptosis},
  author={Penny Clarke and Roberta L Debiasi and Suzanne M Meintzer and Bridget Robinson and Kenneth M. Tyler},
  journal={Apoptosis},
  year={2005},
  volume={10},
  pages={513-524}
}
Virus-induced activation of nuclear factor-kappa B (NF-κB) is required for Type 3 (T3) reovirus-induced apoptosis. We now show that NF-κB is also activated by the prototypic Type 1 reovirus strain Lang (T1L), which induces significantly less apoptosis than T3 viruses, indicating that NF-κB activation alone is not sufficient for apoptosis in reovirus-infected cells. A second phase of virus-induced NF-κB regulation, where NF-κB activation is inhibited at later times following infection with T3… CONTINUE READING

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