Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine.

@article{Fang2006InhibitionON,
  title={Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine.},
  author={Qin Fang and Hong Sun and Denise M. Arrick and William G Mayhan},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 2},
  pages={
          631-6
        }
}
Our goals were to determine whether chronic exposure to nicotine alters nitric oxide synthase (NOS)-dependent reactivity of cerebral (pial) arterioles and to identify a potential role for NADPH oxidase in impaired NOS-dependent responses during chronic exposure to nicotine. We measured in vivo diameter of pial arterioles to NOS-dependent (acetylcholine and ADP) and -independent (nitroglycerin) agonists in saline-treated rats and rats chronically treated with nicotine (2 mg.kg(-1).day(-1) for 2… CONTINUE READING

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