Inhibition of N-linked glycosylation causes apoptosis in hamster BHK21 cells.

  title={Inhibition of N-linked glycosylation causes apoptosis in hamster BHK21 cells.},
  author={Masayuki Yoshimi and Takeshi Sekiguchi and Nobumasa Hara and Takeharu Nishimoto},
  journal={Biochemical and biophysical research communications},
  volume={276 3},
The tsBN7 cell line is one of the temperature-sensitive mutants for cell proliferation derived from hamster BHK21 cell line. It has a mutation in the DAD1 gene and enters apoptosis at the restrictive temperature of 39 degrees C. The defect of Dad1p causes a loss of N-linked glycosylation; therefore, it was thought that an inhibition of N-linked glycosylation induced apoptosis.However, tunicamycin, a potent inhibitor of N-linked glycosylation, had not caused apoptosis in wild-type BHK21 cells… CONTINUE READING

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