Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3.

@article{Choi2004InhibitionON,
  title={Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3.},
  author={Jin-hyuk Choi and K. W. Chun and Avraham Raz and Reuben Lotan},
  journal={Cancer biology & therapy},
  year={2004},
  volume={3 5},
  pages={447-52}
}
The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) induces apoptosis in a variety of human cancer cells including breast carcinoma and this property may be important for its chemopreventive and therapeutic effects. Resistance to 4HPR has been described, however, the molecular mechanisms underlying sensitivity or resistance to this retinoid are not clear. Recently, it has been shown that the carbohydrate-binding protein galectin-3, which has been implicated in tumor progression… CONTINUE READING