Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1).

  title={Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1).},
  author={Markus Hartl and Andrea Nist and Mohammad Imran Khan and Taras Valovka and Klaus Bister},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 14},
Cell transformation by the Myc oncoprotein involves transcriptional activation or suppression of specific target genes with intrinsic oncogenic or tumor-suppressive potential, respectively. We have identified the BASP1 (CAP-23, NAP-22) gene as a novel target suppressed by Myc. The acidic 25-kDa BASP1 protein was originally isolated as a cortical cytoskeleton-associated protein from rat and chicken brain, but has also been found in other tissues and subcellular locations. BASP1 mRNA and protein… CONTINUE READING
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