Inhibition of Multidrug Resistance by SV40 Pseudovirion Delivery of an Antigene Peptide Nucleic Acid (PNA) in Cultured Cells

@inproceedings{Macadangdang2011InhibitionOM,
  title={Inhibition of Multidrug Resistance by SV40 Pseudovirion Delivery of an Antigene Peptide Nucleic Acid (PNA) in Cultured Cells},
  author={Benjamin R Macadangdang and Ning Zhang and Paul E. Lund and Andrew Marple and Mitsunori Okabe and Michael M. Gottesman and Daniel H. Appella and Chava Kimchi-Sarfaty},
  booktitle={PloS one},
  year={2011}
}
Peptide nucleic acid (PNA) is known to bind with extraordinarily high affinity and sequence-specificity to complementary nucleic acid sequences and can be used to suppress gene expression. However, effective delivery into cells is a major obstacle to the development of PNA for gene therapy applications. Here, we present a novel method for the in vitro delivery of antigene PNA to cells. By using a nucleocapsid protein derived from Simian virus 40, we have been able to package PNA into… CONTINUE READING

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