Corpus ID: 36505365

Inhibition of Microtubules and Cell Cycle Arrest by a New 1-Deaza-7 , 8-dihydropteridine Antitumor Drug , CI 980 , and by Its Chiral Isomer , NSC 6138631

  title={Inhibition of Microtubules and Cell Cycle Arrest by a New 1-Deaza-7 , 8-dihydropteridine Antitumor Drug , CI 980 , and by Its Chiral Isomer , NSC 6138631},
  • Nsc
  • Published 2007
CI 980 (NSC 613862; [S-(-)]) and NSC 613863 [R-(+)] are the two chiral isomers of ethyl 5-amino 1,2-dihydro-2-methyl-3.phenylpyrido[3,4b]pyrazin-7-ylcarbamate (NSC 370147), which is a mitotic inhibitor with in vivo and in vitro activity against murine multidrug-resistant sublines. We have characterized the inhibition of in vitro microtubule assembly by the S (CI 980) and R (NSC 613863) enantiomers, their actions on the cytoplasmic microtubule network of epithelial-like PtK2 cells, and on the… Expand

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