Inhibition of Membrane-associated Calcium-independent Phospholipase A 2 as a Potential Culprit of Anthracycline Cardiotoxicity 1

Administration of anthracyclines, a family of highly effective anticancer drugs, is associated with a cumulative dose-related cardiomyopathy, the etiology of which remains poorly understood. We have discovered that administration of the anthracyclines leads to a marked inhibition of membrane-associated calcium-independent phospholipase A2 (iPLA2) both in… CONTINUE READING