Inhibition of Matrix Metalloproteinases by Tea Catechins and Related Polyphenols

@article{Isemura1999InhibitionOM,
  title={Inhibition of Matrix Metalloproteinases by Tea Catechins and Related Polyphenols},
  author={M. Isemura and K. Saeki and T. Minami and S. Hayakawa and T. Kimura and Y. Shoji and M. Sazuka},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={878}
}
We have reported that green tea infusion inhibited in vitro invasion and in vivo metastasis of murine tumor cells. 1 Since matrix metalloproteinases (MMPs) play roles in these processes, we examined whether green tea catechins inhibit MMPs from the murine tumor cells. 2 Mouse Lewis lung carcinoma LL2-Lu3 cells were cultured in serum-free medium Cosmedium 001, and MMPs were partially purified from the medium by affinity chromatography with gelatin-agarose. Gelatin zymography showed that the… Expand
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The results suggest that theaflavin, theAFlavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells. Expand
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  • 1999