Inhibition of Matrix Metalloproteinases by Tea Catechins and Related Polyphenols

  title={Inhibition of Matrix Metalloproteinases by Tea Catechins and Related Polyphenols},
  author={M. Isemura and K. Saeki and T. Minami and S. Hayakawa and T. Kimura and Y. Shoji and M. Sazuka},
  journal={Annals of the New York Academy of Sciences},
We have reported that green tea infusion inhibited in vitro invasion and in vivo metastasis of murine tumor cells. 1 Since matrix metalloproteinases (MMPs) play roles in these processes, we examined whether green tea catechins inhibit MMPs from the murine tumor cells. 2 Mouse Lewis lung carcinoma LL2-Lu3 cells were cultured in serum-free medium Cosmedium 001, and MMPs were partially purified from the medium by affinity chromatography with gelatin-agarose. Gelatin zymography showed that the… Expand
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
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Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols
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Polyphenol (-)-epigallocatechin gallate inhibits apoptosis induced by irradiation in human HaCaT keratinocytes.
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Paclitaxel/epigallocatechin gallate coloaded liposome: a synergistic delivery to control the invasiveness of MDA-MB-231 breast cancer cells.
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A review of propolis antitumor action in vivo and in vitro
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Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins.
The results suggest that theaflavin, theAFlavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells. Expand
Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells.
Results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells. Expand
Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells.
The peroral administration of green tea infusion reduced the number of lung colonies of mouse Lewis lung carcinoma cells in a spontaneous metastasis system. The experiments with artificiallyExpand
  • et al.
  • 1999