Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species.

@article{Wesolowska2007InhibitionOM,
  title={Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species.},
  author={Olga Wesolowska and Jerzy Wiśniewski and No{\'e}lia Duarte and Maria-Jos{\'e} U. Ferreira and Krystyna Michalak},
  journal={Anticancer research},
  year={2007},
  volume={27 6B},
  pages={4127-33}
}
BACKGROUND A search for inhibitors of multidrug resistance (MDR)-associated protein 1 (MRP1) was performed among the compounds isolated from Euphorbia species, plants traditionally used in folk medicine. MATERIALS AND METHODS Fifteen compounds with terpenic or phenolic structures (macrocyclic and polycyclic diterpenes, coumarins, stilbenes and flavonoids) were isolated from the methanol extracts of Euphorbia lagascae and Euphorbia tuckeyana or obtained by derivatization. A functional test… CONTINUE READING