Inhibition of MRP 1 / ABCC 1 , MRP 2 / ABCC 2 , and MRP 3 / ABCC 3 by Nucleoside , Nucleotide , and Non-Nucleoside Reverse Transcriptase Inhibitors

  • Published 2007

Abstract

Many drug interactions with drugs used for the therapy of human immunodeficiency virus (HIV) occur at the level of different cytochrome P450 isozymes. Increasing evidence suggests that antiretrovirals may also modify activity and expression of active drug transport systems. Such interactions may alter drug absorption, elimination, and also drug distribution… (More)

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