Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.

@article{Cheng2019InhibitionOM,
  title={Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.},
  author={David Xi Cheng and Jihan Talib and Christopher Peter Stanley and Imran Rashid and Erik Micha{\"e}lsson and Eva-Lotte Lindstedt and Kevin D Croft and Anthony J Kettle and Ghassan J. Maghzal and Roland Stocker},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2019},
  pages={
          ATVBAHA119312725
        }
}
Objective- Inflammation-driven endothelial dysfunction initiates and contributes to the progression of atherosclerosis, and MPO (myeloperoxidase) has been implicated as a potential culprit. On release by circulating phagocytes, MPO is thought to contribute to endothelial dysfunction by limiting NO bioavailability via formation of reactive oxidants including hypochlorous acid. However, it remains largely untested whether specific pharmacological inhibition of MPO attenuates endothelial… CONTINUE READING
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