Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis.

@article{Sarkar2016InhibitionOM,
  title={Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis.},
  author={Jaganmay Sarkar and Suman Kumar Nandy and Animesh Chowdhury and Tapati Chakraborti and Sajal Chakraborti},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={84},
  pages={340-347}
}
Green tea polyphenolic catechins have been shown to prevent various types of diseases such as pulmonary hypertension (PAH), cancer and cardiac and neurological disorders. Matrix metalloproteinases (MMPs) play an important role in the development of PAH. The present study demonstrated that among the four green tea catechins (EGCG, ECG, EC and EGC), EGCG and ECG inhibit pro-/active MMP-9 activities in pulmonary artery smooth muscle cell culture supernatant. Based on the above, we investigated the… CONTINUE READING

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