Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

@inproceedings{Cui2012InhibitionOM,
  title={Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia},
  author={Jiankun Cui and Shanyan Chen and Chunyang Zhang and Fanjun Meng and Wei Wu and Rong Hu and Or Hadass and Tareq M Lehmidi and Gregory J Blair and Mijoon Lee and Mayland Chang and Shahriar Mobashery and Grace Y Sun and Zezong Gu},
  booktitle={Molecular Neurodegeneration},
  year={2012}
}
BackgroundCerebral ischemia has been shown to induce activation of matrix metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the neurovasculature, resulting in blood–brain barrier breakdown, hemorrhage and neurodegeneration. We previously reported that the thiirane inhibitor SB-3CT, which is selective for gelatinases (MMP-2 and −9), could antagonize neuronal apoptosis after transient focal cerebral ischemia.ResultsHere, we used a fibrin-rich clot to occlude… CONTINUE READING
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