Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses.

  title={Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses.},
  author={Philip G Stevenson and Stacey Efstathiou and Peter C. Doherty and Paul J Lehner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 15},
The gamma-herpesviruses, in contrast to the alpha- and beta-herpesviruses, are not known to inhibit antigen presentation to CD8(+) cytotoxic T lymphocytes (CTLs) during lytic cycle replication. However, murine gamma-herpesvirus 68 causes a chronic lytic infection in CD4(+) T cell-deficient mice despite the persistence of a substantial CTL response, suggesting that CTL evasion occurs. Here we show that, distinct from host protein synthesis shutoff, gamma-herpesvirus 68 down-regulates surface MHC… CONTINUE READING
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