Inhibition of MHC-I by Brucella abortus is an early event during infection and involves EGFR pathway.


Brucella abortus is able to persist inside the host despite the development of potent CD8+ T-cell responses. We have recently reported the ability of B. abortus to inhibit the interferon-γ-induced major histocompatibility complex (MHC)-I cell surface expression on human monocytes. This phenomenon was due to the B. abortus-mediated retention of MHC-I… (More)
DOI: 10.1038/icb.2016.111


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